Name: Jeff Eriksen

Email: jeriksen@teleport.com

CompanyName: Electrical Geodesics, Inc.

Country: USA

Abstract: Static conductivity information of the various head tissues is vital to proper solution of the forward problem in EEG and MEG. We assume that the tissue geometry is already known from structural tomography, and desire to estimate the conductivities of the major regions. These are potentially anisotropic, but purely resistive since we are only interested in low frequencies in the EEG range. To solve this estimation problem we use a 3D FEM of the head for the forward problem, derived from full head CT or MRI. The inverse problem consists of an iterative algorithm that minimizes the difference between measured and model data for multiple current injection pairs. We have built a device to enable selection of various injection electrode pairs from the full set of 128 electrodes in our Geodesics Sensor Net, while allowing measurement of the induced potential field with the remaining 126 electrodes. We can switch between several sinusoidal current levels (1 to 100 microam!
ps) and frequencies (1 to 200 Hz) to accomodate phantom or human use. The current source is battery powered and galvanically isolated from the EEG recording system. Within 30 minutes we can acquire data from all 8,000+ pairs and then extract the signal amplitudes from the ongoing EEG.

In simulation studies with spherical models, we have found that we can robustly recover the four conductivities representing the brain, CSF, skull, and scalp to high precision and accuracy in the presence of reasonable amounts of noise. We have verified the complete hardware/software system in a single physical phantom cylinder, and are now constructing a 3-layer cylinder with known conductities for additional validation. We will next apply this methodology to human recordings with a 4-sphere model and then the realistic FEM model. The latter will first be set up with 4 conductivities, then refined in stages adding skull detail followed by ventricles, gray-white matter differentiation, and finally anisotropies.

Close Window